Melanin: The Amazing Electronically-Active Semiconductor


Melanin (also spelled melanine or melano-; from Ancient Greek μέλας, black, dark colored) is a broad term for a group of natural pigments found in most organisms. Melanin is produced by pigment cells called melanocytes through a process known as melanogenesis. It is found in the skin and hair of mammals, as well as the feathers, fur, and eyespots of some animals. In humans, melanin is the primary determinant of skin color.

Melanin examples

What is Melanin?

Melanin is a naturally occurring pigment in the human body that plays several vital roles beyond its aesthetic function. It helps to protect your skin from the sun’s UV rays and, in some cases, even tanning, acting as a natural sunscreen by absorbing harmful radiation. Moreover, it serves as an essential sound absorber for the ear, contributing to our ability to process sounds by preventing echoes and enhancing auditory clarity. Interestingly, melanin is not just confined to the skin and ears; it is also present in the hair and eyes, influencing their color and providing additional protection.

However, certain types of melanin can lead to health complications, such as Parkinson’s disease, if they accumulate over time in the brain and alter normal cellular function. These melanins are produced through oxidation or damage to cells, which can be triggered by various environmental and genetic factors. Understanding the dual nature of melanin—its protective benefits and potential health risks—is crucial for advancing research and treatment of associated conditions.

The Five Types of Melanin

Eumelanin is a brownish-black pigment that provides skin and hair with a tanning effect, and it also protects the skin from sunburn. Pheomelanin is what causes blondes to have blonde hair, and its reddish hue can be seen in some pink flamingos. Neuromelanin is what gives the substantia nigra in our brains its color; it’s also an essential sound absorber in our ears. Allomelanin is produced when melanocytes respond to oxidative stress (the process of generating chemicals within cells that damage molecules) and is associated with skin cancer. Pyomelanin results when melanocytes are killed off by UV light, which is why tanning beds are so dangerous.

What makes Melanin so special?

Unlike other semiconductors, which are complex, brittle, and fragile, melanin is soft and flexible, allowing it to conform easily to the shape of the underlying skin cells. This unique property makes it a fantastic skin protector that shields against the harmful ultraviolet (UV) rays emitted by the sun, as well as extreme heat and cold temperatures, thereby playing a crucial role in maintaining skin health.

Furthermore, melanin also protects us by effectively absorbing ionizing radiation, which can be detrimental to our cellular structures. Its protective functions extend beyond just physical barriers; additionally, we rely on melanin as an essential component of our immune system, as it helps block harmful bacteria and viruses while also aiding in the prevention of infections. In this way, melanin contributes not only to the pigmentation of our skin but also to our overall well-being and resilience against environmental stressors.

How can we use this amazing semiconductor in our everyday lives?

Melanin is a skin protector that converts ultraviolet light into heat and sound, effectively serving as a natural shield for our skin. This remarkable ability can be harnessed to treat sunburns, providing much-needed relief, and helps to protect the skin from the harsh effects of the sun’s ultraviolet rays. As melanin absorbs UV radiation, it not only produces heat, which contributes to warmth and comfort, but it also decreases the risk of cancerous cells forming on the skin, offering potential preventive benefits. Furthermore, melanin can be utilized to produce electricity by converting light energy into other forms, such as thermal or sound energy, thus presenting an innovative avenue for alternative energy sources.

This property could be instrumental in solar power applications, demonstrating its versatility beyond just skin protection. In medical research, it has also been shown to protect against the side effects of radiation therapy, such as hair loss, nausea, and vomiting, enhancing the quality of life for patients undergoing treatment. The multifaceted functions of melanin highlight its significance not only in dermatological health but also in renewable energy and cancer care, paving the way for exciting future developments in these fields.

The Future Applications of Melanin

In addition to being excellent sound absorbers, they may also act as natural antennas, allowing computers and other electrical devices around us to sense things more easily. For example, a touchscreen display might respond more effectively to touch if it incorporated melanin.

Another potential use of melanin in the future is for biofuel production. Skin cells have been genetically modified to express the pigment gene, allowing them to produce eumelanin on their own when grown in a laboratory environment. These skin cells are then added to yeast cultures, which feed on sugar and convert it into alcohol. The result? The same brown color is found in our skin, but without any toxic byproducts from industrial processes.

Through further research and experimentation, we can develop an all-natural skin protector that not only safeguards your skin from the sun’s damaging rays but also serves as an alternative fuel source.  Melanin anyone? –MM

References:

Meredith, P., & Sarna, T. (2006). The physical and chemical properties of eumelanin. Pigment Cell Research, 19(6), 572–594. https://doi.org/10.1111/j.1600-0749.2006.00345.xhttps://doi.org/10.1111/j.1600-0749.2006.00345.x
Meredith, P., Bettinger, C. J., Irwin, M. D., et al. (2013). Electronic and optical properties of bio‐molecular melanins. Reports on Progress in Physics, 76(3), 034501. https://doi.org/10.1088/0034-4885/76/3/034501https://doi.org/10.1088/0034-4885/76/3/034501
Mostert, B. J., Powell, B. J., Pratt, F. L., et al. (2012). Role of semiconducting properties of eumelanin in its radical scavenging activity. Soft Matter, 8(7), 1929–1937. https://doi.org/10.1039/C1SM06830Ghttps://doi.org/10.1039/C1SM06830G
Pinto, N. J., Cicoira, F., & Diao, P. (2008). Melanin as an organic semiconductor: Water‐induced self-doping and conductivity. Journal of Applied Physics, 103(8), 083111. https://doi.org/10.1063/1.2901173https://doi.org/10.1063/1.2901173
Di Mauro, E., Calcagno, L., & Amato, M. E. (2017). Eumelanin‐based multifunctional battery-free energy-harvesting and storage devices. ChemPlusChem, 82(4), 656-664. https://doi.org/10.1002/cplu.201600561https://doi.org/10.1002/cplu.201600561
Kim, Y. J., & Park, J. (2016). Conductive natural biomaterials and their applications to electronic devices. Journal of Industrial and Engineering Chemistry, 38, 33–45. https://doi.org/10.1016/j.jiec.2016.04.014https://doi.org/10.1016/j.jiec.2016.04.014
D’Ischia, M., Wakamatsu, K., Cicoira, F., et al. (2015). Melanins and melanogenesis: From pigment cells to human health and technological applications. Pigment Cell & Melanoma Research, 28(5), 520–544. https://doi.org/10.1111/pcmr.12413https://doi.org/10.1111/pcmr.12413
Mostert, B. J., McCall, K. L., Jung, W., et al. (2014). Electrical conductivity in a biomolecular pigmented semiconductor—An electrochemical and biophysical study of melanin. Journal of Physical Chemistry B, 118(25), 8442–8450. https://doi.org/10.1021/jp503207jhttps://doi.org/10.1021/jp503207j
Ganbold, E., Shim, W., & Kim, J. (2019). Biocompatible melanin nanomaterials: Potentials and challenges in cancer therapy. Nanomaterials, 9(4), 496. https://doi.org/10.3390/nano9040496https://www.mdpi.com/2079-4991/9/4/496
Mostert, B. J., Meredith, P., & Nguyen, V. (2012). Engineering conductivity in melanin by control of protonic and electronic transport. Applied Physics Letters, 100(9), 093701. https://doi.org/10.1063/1.3689773https://doi.org/10.1063/1.3689773
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